Successful reintroduction and continuation of nivolumab in a patient with immune checkpoint inhibitor-induced bullous pemphigoid

Many advanced cancers, such as melanoma, evade the immune system by exploiting negative feedback mechanisms.Immune checkpoint Cooling Racks/Grates inhibitor (ICI) therapy dramatically enhances immune surveillance and has revolutionized treatment of advanced melanoma.However, ICI therapy is also associated with multiple cutaneous adverse events.We d

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Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress

Abstract Due to the overexpression or amplification of human epidermal growth factor receptor 2 (HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on HER2-targeted therapies.Deregulation in HER2 signaling pathways is accompanied by sustained tumor cells growth concomitant with their migration and also tumor angiogen

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